Prednisolonum from what this synthetic hormonal analog of the hormones of a cortisone and hydrocortisone emitted by bark of an adrenal gland helps? Medicine renders the expressed anti-exudative, antishock, antiinflammatory, antiallergenic, anti-toxic action. The application instruction orders to use the drug Prednisolonum at an allergy, hepatitis, rheumatism.
Structure and form of release
Make the following kinds of a medicine:
Solution for in/in and introductions of 30 mg/ml in oil – 1 ml; 15 mg/ml – 2 ml.
Mg tablets 1 and 5.
Ointment for outside therapy of 0,5%.
Drops eye 0,5%.
The composition of prednisone from mexico in ampoules includes active substance in concentration of 30 mg/ml, and also sodium pyrosulphite (E223 additive), dinatrium эдетат, niacinamide, sodium hydroxide, water for and.
The tablets Prednisolonum from what medicine according to many indications helps, include: 1 or 5 mg of active substance and excipients.
Prednisolonum ointment contains 0,05 g of active substance, soft white paraffin, glycerin, stearic acid, methyl – and пропилпарагидроксибензоат, Cremophor A25 and A6, the purified water.
Pharmacological properties
Drug (ointment, drops, pricks, tablets) Prednisolonum from what helps at difficult pathologies, renders the expressed antiinflammatory, antiallergenic, anti-exudative, antishock, anti-toxic action. The antiinflammatory effect of Prednisolonum is reached, mainly, with the participation of cytosolic receptors of glucocorticosteroids.
Hormone-receptor complex, getting into a skin target cell kernel (keratinotsita, fibroblasts, lymphocytes), strengthens an expression of the genes coding synthesis of lipokortin which inhibit a phospholipase of A2 and reduce synthesis of products of metabolism of arachidonic acid of cyclic endoperoxides, prostaglandins and thromboxane.
Anti-proliferative effect of Prednisolonum is connected with braking of synthesis of nucleic acids (first of all DNA) in cells of a basal layer of epidermis and fibroblasts of a derma. The antiallergic effect of drug is caused by reduction of number of basophiles, direct inhibition of synthesis and secretion of biologically active agents.
At intake it is well soaked up from a GIT. The maximum concentration in a blood plasma is reached in 90 minutes after reception.
Prednisolonum — hormonal or not?
Prednisolonum is a hormonal drug for topical and system administration of average duration of action. Drug by 4 — 5 times is more active in comparison with a cortisone and by 3 — 4 times in comparison with a hydrocortisone at use inside. Unlike a cortisone and a hydrocortisone Prednisolonum does not cause a noticeable delay of sodium and water and only slightly increases release of potassium.
Medicine Prednisolonum: from what helps
Indications to use of tablets and solution for injections
System use is reasonable at:
hepatitis;
eosinophilic and aspiration pneumonia, tubercular meningitis, a pulmonary tuberculosis (as addition to specific therapy);
autoimmune and other diseases of skin (including a disease of Dyuringa, psoriasis, eczema, a pemphigus, a Lyell’s disease, exfoliative dermatitis);
multiple sclerosis;
granulematozny thyroiditis;
lung cancer (with cytostatics);
acute and chronic diseases which are followed by an inflammation in joints and circumarticular fabric;
allergic diseases;
wet brain;
inflammatory gastrointestinal diseases;
asthmatic status and OH;
to small chorea, rheumatic fever, rheumatic carditis;
the hypercalcemia developing against the background of oncological diseases.
diseases of the hemopoietic bodies and blood (leukoses, anemias and systems of a hemostasis of a disease connected with defeat);
inborn adrenal struma (IAS) or dysfunction of their bark;
diffusion diseases of connecting fabric;
hypoglycemic states;
nephrotic syndrome;
autoimmune diseases;
intersticial diseases of pulmonary fabric (fibrosis, acute alveolitis, sarcoidosis, etc.);
primary and secondary hypocorticoidism (including after an adrenalectomy);
diseases of eyes (including autoimmune and allergic; including uveites, allergic ulcer keratitis, allergic conjunctivitis, sympathetic ophthalmia, choroiditis, iridocyclitis, not purulent keratitis, etc.).
Indications to use of pricks are medical emergencies, for example, a bad attack of food allergy or an acute anaphylaxis. After several days of parenteral use of the patient, as a rule, transfer to the tableted Prednisolonum form.
The indication to use of tablets are the pathologies having chronic character and proceeding in a severe form (for example, bronchial asthma).
Also solution and the tablets Prednisolonum apply to the prevention of graft rejection and stopping of nausea/vomiting at the patients receiving cytostatics.
For what appoint eye drops?
Drops in eyes are appointed for stopping of the inflammations of the noninfectious nature, and also inflammations striking a front segment of an eye which develop after an injury of an eye or ophthalmologic operation.
Topical administration of Prednisolonum is reasonable at the following diseases of eyes:
iritis;
sclerite;
blepharitis;
keratitis;
episcleritis;
sympathetic ophthalmia;
iridocyclitis;
blefarokonjyunktivit;
allergic conjunctivitis;
uveitis.
Ointment Prednisolonum: for what appoint?
As outside means Prednisolonum is applied from an allergy and to treatment inflammatory skin diseases of not microbic etiology. Indications to ointment use following:
dermatitis (contact, allergic and atopic);
diskoidny lupus erythematosus;
psoriasis;
eczema;
limited neurodermatitis;
small tortoiseshell;
erythrosis;
toksikodermiya.
Contraindications
The instruction prohibits use of Prednisolonum in the following cases:
peptic ulcer of a stomach and duodenum;
active form of tuberculosis;
nephrite (inflammation of kidneys);
acute endocarditis (inflammation of internal cardial cavities);
severe forms of an idiopathic hypertensia (permanent rise in arterial pressure);
diabetes mellitus and Itsenko-Cushing’s disease;
остебпороз;
recently undergone operations;
psychoses;
senile age;
syphilis,
circulatory unefficiency of the III stage,
pregnancy.
Drug Prednisolonum: application instruction
Pricks
Solution is entered intravenously, intramusculary and vnutrisustavno. The way of introduction and a dosage of Prednisolonum (Prednisolonum Nikomed, Prednisolonum of a gemisuktsinat) are selected individually attending physician taking into account a type of pathology, weight of a condition of the patient, localization of the struck body.
At serious and life-threatening conditions to the patient appoint pulse therapy using during a short span of ultrahigh doses. Within 3-5 days to it by method of intravenous drop infusion daily enter 1-2 g of Prednisolonum. Duration of the procedure is from 30 minutes till 1 o’clock.
During treatment the dosage is adjusted depending on the response of an organism of the patient to therapy. Optimum it is considered to enter Prednisolonum in / century. For intra joint introduction of an ampoule with Prednisolonum use only when pathological process struck fabrics in a joint.
Positive dynamics is a reason for transfer of the patient into tablets or candles with Prednisolonum. Treatment by tablets is continued before development of permanent remission. At impossibility of administration of Prednisolonum in/in, medicine should be entered deeply into a muscle. However it is necessary to consider that at such way it is soaked up more slowly.
Depending on pathology the dose can fluctuate within 30-1200 mg/days (with the subsequent its decrease).
To children aged from two months till 1 year enter from 2 to 3 mg/kg. A dosage to children from a year to 14 years — 1-2 mg/kg (in the form of slow, lasting 3 minutes, an intramuscular injection). If necessary in 20-30 minutes medicine is entered repeatedly in the same dose.
At damage of a large joint enter from 25 to 50 mg of Prednisolonum into it. Enter from 10 to 25 mg into joints of average size, in small — from 5 to 10 mg.
Application instruction of the tablets Prednisolonum
Transfer to reception of tablets of the patient, following the principle of gradual cancellation of GKS.
In case of use of ZGT sick appoint from 20 to 30 mg of Prednisolonum a day. A maintenance dose — from 5 to 10 mg/days. At some pathologies — for example, at a nephrotic syndrome — it is reasonable to appoint higher doses.
For children the starting dose makes 1-2 mg/kg/days (it is necessary to divide it into 4-6 receptions), supporting — from 0,3 to 0,6 mg/kg/days. At appointment consider a day-night secretory rhythm of endogenous steroid hormones.
Recommendations concerning use of drugs of different producers identical. That is the instruction on tablets Nikomed does not differ from the instruction on the tablets made by the Biosintez company.
Use of eye drops
Instillations by drug spend 3 rubles/days, digging in 1-2 drops of solution in a conjunctival cavity of the affected eye. In an acute phase of a disease the procedure of an instillation is allowed to be repeated every 2-4 hour.
To the patients who underwent an ophthalmologic operation, drops are appointed to 3-5 days after surgical intervention.
Ointment Prednisolonum: application instruction
Ointment is means of outside therapy. It is necessary to apply on affected areas of skin it with a thin layer to from 1 to 3 rubles/days. It is possible to apply an occlusive bandage for strengthening of effect the limited pathological centers.
In case of use for children is more senior than one-year-old age drug should be used shorter course. Also it is necessary to exclude the actions promoting strengthening of absorption and a resorption of Prednisolonum (the occlusal, fixing, warming bandages).
How it is long possible to accept Prednisolonum?
Therapy by glucocorticosteroids is directed to achievement of the maximum effect by minimum possible doses.
Duration of treatment depends on the diagnosis of the patient and individual reaction to treatment. In some cases the course lasts up to 6 days, at ZGT it lasts for months. Duration of outside therapy using ointment Prednisolonum usually from 6 to 14 days.
Side effect
Use of drug can cause the following negative reactions of an organism:
eels;
spasms;
osteoporosis (it is very rare – pathological fractures of bones, an aseptic necrosis of a head humeral and a femur);
trophic changes of a cornea;
disorientation;
delay of sexual development at children;
increase in intracranial pressure;
skin rash;
gipokaliyemichesky syndrome (hypopotassemia, arrhythmia, mialgiya or spasm of muscles, unusual weakness and fatigue);
sleeplessness;
oppression of function of adrenal glands;
steroid stomach ulcer and duodenum;
delay of liquid and sodium in an organism (peripheral hypostases);
hallucinations;
the increased calcium removal;
nausea, vomiting;
increase in body weight;
decrease in tolerance to glucose;
increase in the ABP;
gastrointestinal bleedings and perforation of a wall of a GIT;
ECG changes characteristic of a hypopotassemia;
increase or loss of appetite;
increase in intraocular pressure with possible injury of an optic nerve;
rupture of sinews of muscles;
euphoria;
itch;
striya;
meteorism;
Icenco-Cushing syndrome (crescent-shaped face, obesity of pituitary type, hirsutism, increase in the ABP, dysmenorrhea, amenorrhea, muscular weakness, striya);
the increased perspiration;
dizziness;
nervousness or concern;
maniac-depressive psychosis;
steroid diabetes mellitus or manifestation of a latent diabetes mellitus;
delay of growth and processes of ossification at children (premature closing of epiphyseal regions of growth);
arrhythmias;
erosive esophagitis;
development or exacerbation of infections (emergence of this side effect is promoted jointly by the applied immunodepressants and vaccination);
acute anaphylaxis;
tendency to development secondary bacterial, fungal or, viral infections of eyes;
hiccups;
paranoia;
withdrawal;
depression;
headache;
bradycardia (up to a cardiac standstill);
digestion disturbance;
decrease in muscle bulk (atrophy);
the slowed-down healing of wounds.
Withdrawal signs
“Withdrawal” can become one of effects of use of GKS. Its weight depends on a functional condition of bark of adrenal glands. In mild cases after the treatment termination by Prednisolonum the indisposition, weakness, bystry fatigue, muscular pains, appetite loss, a hyperthermia, an aggravation of a basic disease are possible.
In hard cases at the patient hypoadrenal crisis which is followed by vomiting, spasms, a collapse can develop. Without introduction of GKS to short terms there comes death from acute cardiovascular insufficiency.
How “to get down” from Prednisolonum?
Treatment by Prednisolonum should be completed gradually. The dose decline is carried out, weekly reducing the used dose on 1/8 or accepting the last dose every other day and reducing it at the same time on 1/5 (this way more bystry).
At a bystry way in day without Prednisolonum stimulation of adrenal glands using UVCh DKV silt on their projection, reception of ascorbic acid (500 mg/days), administration of insulin in the accruing doses is shown to the patient (starting — 4 PIECES, further on each reception raise it on 2 PIECES; the highest dose — 16 PIECES).
Insulin should be pricked before a breakfast, within 6 hours after an injection of people has to remain under observation.
If Prednisolonum is appointed at bronchial asthma, it is recommended to pass to inhalation steroids. If the indication to use is the autoimmune disease — on soft cytostatics.
At pregnancy and feeding by a breast
Purpose of GKS at pregnancy and to women of childbearing age is admissible only in cases when the estimated advantage for mother exceeds potential risk for a fruit. Women of childbearing age have to be informed on potential risk of therapy of group of companies for a fruit.
Prednisolonum is emitted with breast milk and can cause in the child who is on breastfeeding, undesirable effects (a growth inhibition or oppression of development of endogenous adrenal hormones). In need of use of drug in the period of a lactation it is necessary to stop breastfeeding.
At pregnancy, especially in the first trimester, it is necessary to appoint Prednisolonum with extra care.
Special instructions
Treatment by Prednisolonum needs to be stopped slowly, smoothly reducing a dose. To the patients having psychoses in the anamnesis, it is allowed to appoint high doses only under strict control of the doctor.
Medicine Prednisolonum analogs
Structural analogs on active ingredient:
Solyu-Dekortin H25.
Solyu-Dekortin H50.
Prednisolonum of 5 mg Yenafarm.
Prednisolonum Nikomed.
Prednisolonum буфус.
H20 Decortinum.
H5 Decortinum.
Solyu-Dekortin H250.
Sodium Prednisolonum phosphate.
Prednizolon-Fereyn.
Prednizol.
H50 Decortinum.
Medopred.
Prednisolonum гемисукцинат.
Similar drugs with the close mechanism of action:
Betamethasone.
Triamcinolonum.
Kenalogum.
Flosteron.
Dexamethum.
Hydrocortisone.
Dexasonum.
Dexamethasone.
Ректодельт.
Lemod.
Deltason.
Medrolum.
Methypredum.
Price
In Moscow, SPb the drug Prednisolonum can be bought for 26-110 rubles. Its price in Kiev reaches 30-50 hryvnias. Drugstores suggest to get tablets in Minsk for 1-3 is white. rubles. The price in Kazakhstan makes 1200 tenges.
Opinions of patients and doctors
Reviews of Prednisolonum in tablets and pricks are quite contradictory: on the one hand medicine very effective, with another – has a wide range of side effects and at prolonged use causes a withdrawal. Also some people, drug, note that a prick painful.
Nevertheless, pricks quite often allow to stop to children and adults very quickly pathological process and even to save life.
“During reception of Prednisolonum getting very hungry. Even at night”.
“Helped the granddaughter to cope with an allergy. But at Prednisolonum there are a lot of side effects which negatively influence an organism in general. As they say: one we treat, another we cripple”.
“After a course of treatment immunity decreased, appetite was just irrepressible. Gradually negative effects of reception of Prednisolonum of course passed.
At long reception of Prednisolonum it is impossible to stop a course of treatment sharply. The daily dose of drug should be reduced gradually. Drug serious so it is possible and it is only necessary to apply it if it is vital”.
“We drink in a complex with an asparkam and calcium glikonaty. There are side effects. We had a gastric disturbance and aggression. Mad appetite.”
